Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Oprm1tm1Jlw
Name:	opioid receptor, mu 1; targeted mutation 1, Jennifer L Whistler
MGI ID:	MGI:3773695
Synonyms:	RMOR, rMOR-R
Gene:	Oprm1  Location: Chr10:6708593-6988209 bp, + strand  Genetic Position: Chr10, 1.85 cM, cytoband A2
Alliance:	Oprm1tm1Jlw page

Germline Transmission:	Earliest citation of germline transmission: J:131412
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted Mutation:    Insertion   Mutation details: The coding region of part of the cytoplasmic tail (FREFCIPTSSTIEQQNSARIRQNTREHPSTANTVDRTNHQ) within exon 3 was replaced with the sequence from the delta opioid peptide receptor (FRQLCRTPCGRQEPGSLRRPRQATTRERVTACTPSQ) and a floxed neo cassette. Expression of the receptor in homozygotes was similar to the endogenous receptor. (J:131412)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Oprm1 Mutation:	53 strains or lines available

Original:	J:131412 Kim JA, et al., Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence. Curr Biol. 2008 Jan 22;18(2):129-35
All:	3 reference(s)