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Slc40a1tm1Nca
Targeted Allele Detail
Summary
Symbol: Slc40a1tm1Nca
Name: solute carrier family 40 (iron-regulated transporter), member 1; targeted mutation 1, Nancy C Andrews
MGI ID: MGI:3771547
Synonyms: Fpnnull
Gene: Slc40a1  Location: Chr1:45947228-45965683 bp, - strand  Genetic Position: Chr1, 23.96 cM, cytoband B
Alliance: Slc40a1tm1Nca page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:129846
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo-cassette replaced exon 6 and part of exon 7 encoding amino acids 172 - 338 including 3 of the 10 predicted transmembrane segments. Immunohistochemical analysis confirmed the absence of protein in a subset of embryos from heterozygous crosses. (J:129846)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc40a1 Mutation:  53 strains or lines available
References
Original:  J:129846 Donovan A, et al., The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 2005 Mar;1(3):191-200
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory