Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pyytm1.1Batt
Name:	peptide YY; targeted mutation 1.1, Rachel L Batterham
MGI ID:	MGI:3771165
Synonyms:	PyyKO
Gene:	Pyy  Location: Chr11:101997502-101998658 bp, - strand  Genetic Position: Chr11, 65.48 cM
Alliance:	Pyytm1.1Batt page

Germline Transmission:	Earliest citation of germline transmission: J:129742
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: An frt-flank neo cassette with a 3' lox P site was inserted upstream of the open reading frame and an additional lox P site was inserted downstream of the open reading frame. Flp-mediated recombination was used to remove the neo cassette and germ line cre-mediated recombination was used to remove the open reading frame. The absence of protein product was confirmed by the absence of protein product in the plasma. (J:129742)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pyy Mutation:	9 strains or lines available

Original:	J:129742 Batterham RL, et al., Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metab. 2006 Sep;4(3):223-33
All:	5 reference(s)