Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Sirt3tm1.1Fwa
Name:	sirtuin 3; targeted mutation 1.1, Frederick W Alt
MGI ID:	MGI:3769234
Synonyms:	Sirt3-
Gene:	Sirt3  Location: Chr7:140443579-140462222 bp, - strand  Genetic Position: Chr7, 86.07 cM, cytoband F4
Alliance:	Sirt3tm1.1Fwa page

Germline Transmission:	Earliest citation of germline transmission: J:129009
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A floxed neo cassette was inserted into intron 3 and an additional loxP site was inserted upstream of exon 2. Cre-mediated recombination was used to remove the neo cassette, exon 2 and exon 3. The absence of protein product was confirmed by western blot analysis on liver and brain extracts. (J:129009)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sirt3 Mutation:	30 strains or lines available

Original:	J:129009 Lombard DB, et al., Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007 Dec;27(24):8807-14
All:	98 reference(s)