Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mapttm1(MAPT)Vln
Name:	microtubule-associated protein tau; targeted mutation 1, Fred Van Leuven
MGI ID:	MGI:3768527
Synonyms:	tau-KOKI
Gene:	Mapt  Location: Chr11:104122216-104222916 bp, + strand  Genetic Position: Chr11, 67.79 cM, cytoband E1
Alliance:	Mapttm1(MAPT)Vln page

Germline Transmission:	Earliest citation of germline transmission: J:96869
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence, Modified isoform(s), Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A human MAPT cDNA encoding the longest tau isoform of 441 amino acids containing four repeats, with 2 N-terminal inserts replaced the endogenous mouse gene. Endogenous mouse Mapt protein is not expressed, and the inserted human gene is expressed in brain driven by a murine Thy1 promoter beginning at P15. (J:96869)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapt Mutation:	428 strains or lines available

Original:	J:96869 Terwel D, et al., Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice. J Biol Chem. 2005 Feb 4;280(5):3963-73
All:	2 reference(s)