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Targeted Allele Detail
Symbol: Twist1tm2Bhr
Name: twist basic helix-loop-helix transcription factor 1; targeted mutation 2, Richard R Behringer
MGI ID: MGI:3768516
Synonyms: Twist13loxPneo, Twist1cko, Twist1flox
Gene: Twist1  Location: Chr12:33957671-33959829 bp, + strand  Genetic Position: Chr12, 14.81 cM, cytoband B-C1
Germline Transmission:  Earliest citation of germline transmission: J:128714
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed neo cassette was inserted into the 3'UTR and an additional loxP site was inserted upstream of exon 1. The neo cassetee was removed by cre-mediated recombination to leave a floxed open reading frame. (J:128714)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Twist1 Mutation:  9 strains or lines available
Original:  J:128714 Chen YT, et al., Generation of a Twist1 conditional null allele in the mouse. Genesis. 2007 Sep;45(9):588-92
All:  39 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory