Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Twist1tm2Bhr
Name:	twist basic helix-loop-helix transcription factor 1; targeted mutation 2, Richard R Behringer
MGI ID:	MGI:3768516
Synonyms:	Twist13loxPneo, Twist1cko, Twist1flox
Gene:	Twist1  Location: Chr12:34007670-34009828 bp, + strand  Genetic Position: Chr12, 14.81 cM, cytoband B-C1
Alliance:	Twist1tm2Bhr page

Germline Transmission:	Earliest citation of germline transmission: J:128714
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site flanked neomycin resistance gene cassette was inserted into the 3' UTR and an additional loxP site was inserted upstream of exon 1. The neo cassette was removed by cre-mediated recombination to leave a floxed open reading frame. (J:128714)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	88 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Twist1 Mutation:	18 strains or lines available

Original:	J:128714 Chen YT, et al., Generation of a Twist1 conditional null allele in the mouse. Genesis. 2007 Sep;45(9):588-92
All:	53 reference(s)