Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Scn1btm2Isom
Name:	sodium channel, voltage-gated, type I, beta; targeted mutation 2, Lori L Isom
MGI ID:	MGI:3768513
Synonyms:	Scn1bflox, Scn1bneo
Gene:	Scn1b  Location: Chr7:30815949-30826428 bp, - strand  Genetic Position: Chr7, 19.3 cM
Alliance:	Scn1btm2Isom page

Germline Transmission:	Earliest citation of germline transmission: J:128713
Parent Cell Line:	Pat5 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: LoxP sites were inserted 190 bp upstream and 220 bp downstream of exon 2. A FRT-flanked neomycin cassette was also inserted further downstream of exon 2. Germline transmission was confirmed by genomic PCR. The presence of the loxP sites or the neocassette was determined not to alter gene expression. (J:128713)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn1b Mutation:	6 strains or lines available

Original:	J:128713 Chen C, et al., Floxed allele for conditional inactivation of the voltage-gated sodium channel beta1 subunit Scn1b. Genesis. 2007 Sep;45(9):547-53
All:	1 reference(s)