Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tlr4lps-Btlr
Name:	toll-like receptor 4; defective lipopolysaccharide response Bruce Beutler
MGI ID:	MGI:3767575
Synonyms:	lps3, Tlr4lps3, defective lipopolysaccharide response 3
Gene:	Tlr4  Location: Chr4:66745788-66765338 bp, + strand  Genetic Position: Chr4, 34.66 cM
Alliance:	Tlr4lps-Btlr page

Strain of Origin:	C57BL/6J
Project Collection:	Beutler Mutagenetix

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: The lps3 phenotype was identified in an ENU mutagenesis screen for mutants with impaired response to Toll-like receptor (TLR) ligands. The mutation is an A-to-T transversion at nucleotide position 2147 of the gene (Genbank Accession NM_021297) that results in replacement of aspartic acid by valine at amino acid position 709 of the receptor protein. (J:128416) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tlr4 Mutation:	90 strains or lines available

Original:	J:128416 Siggs O, et al., An ENU-induced point mutation of Tlr4 ablates immune response to LPS. MGI Direct Data Submission. 2007;
All:	2 reference(s)