Vac14Gt(RRP155)Byg
Gene trapped Allele Detail
|
|
| Symbol: |
Vac14Gt(RRP155)Byg |
| Name: |
Vac14 homolog (S. cerevisiae); gene trap RRP155, BayGenomics |
| MGI ID: |
MGI:3766320 |
| Synonyms: |
Vac14beta-geo |
| Gene: |
Vac14 Location: Chr8:111345217-111447030 bp, + strand Genetic Position: Chr8, 57.59 cM
|
| Alliance: |
Vac14Gt(RRP155)Byg page
|
|
Neural tissue lesions in Vac14Gt(RRP155)Byg/Vac14Gt(RRP155)Byg mice
Show the 2 phenotype image(s) involving this allele.
|
|
|
| Mutant Cell Line: |
RRP155 |
| Germline Transmission: |
Earliest citation of germline transmission:
J:127106
|
| Parent Cell Line: |
Other (see notes) (ES Cell)
|
| Strain of Origin: |
129P2/OlaHsd
|
|
| Allele Type: |
|
Gene trapped (Null/knockout) |
| Mutation: |
|
Insertion of gene trap vector
Vector: pGT0Lxf
Vector Type: gene trap
|
| |
|
Mutation details: A beta-geo gene trap vector inserted into intron 1. Western blot analysis confirmed the absence of protein expression in extracts from primary fibroblasts. In primary fibroblasts levels of phophatidylinositol 3,5-biphosphate and phophatidylinositol 5-phosphate are significantly reduced while levels of phophatidylinositol 3-phosphate are elevated.
(J:127106)
|
| Sequence Tags: |
|
Sequence tag details (1 tag)
| Tag ID |
GenBank ID |
Method |
Tag Location (trapped strand)* |
Select |
|
| Genome Context: |
|
Genome Browser view of this mutation
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Vac14 Mutation: |
41 strains or lines available
|
|
|
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
|
| Original: |
J:127106 Zhang Y, et al., Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17518-23 |
| All: |
7 reference(s) |
|
Analysis Tools
