Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Akap5tm1Gsm
Name:	A kinase anchor protein 5; targeted mutation 1, G Stanley Mcknight
MGI ID:	MGI:3765995
Synonyms:	AKAP150delta36, AKAP150 delta A, D36
Gene:	Akap5  Location: Chr12:76371665-76380927 bp, + strand  Genetic Position: Chr12, 33.73 cM
Alliance:	Akap5tm1Gsm page

Germline Transmission:	Earliest citation of germline transmission: J:127739
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Not Specified) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A stop codon (TAG) replaced the codon for Leu710 (TTA) (L710X), truncating the last 36 residues that are important for binding to protein kinase A (PKA). A loxP-flanked neomycin resistance cassette was also inserted downstream of the lone coding exon. After germ line transmission, the neomycin resistance cassette was removed by crossing with cre-transgenic mice. Western blots for PKA subunits from postsynaptic densities of the forebrain indicated reduced levels of protein, confirming mutation of the targeted gene. (J:127739, J:160134)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Akap5 Mutation:	27 strains or lines available

Original:	J:127739 Lu Y, et al., Age-dependent requirement of AKAP150-anchored PKA and GluR2-lacking AMPA receptors in LTP. EMBO J. 2007 Nov 28;26(23):4879-90
All:	8 reference(s)