Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Ptch1tm1Hahn
Name:	patched 1; targeted mutation 1, Heidi Hahn
MGI ID:	MGI:3764517
Synonyms:	Ptchflox
Gene:	Ptch1  Location: Chr13:63656142-63721274 bp, - strand  Genetic Position: Chr13, 32.8 cM
Alliance:	Ptch1tm1Hahn page

Germline Transmission:	Earliest citation of germline transmission: J:127207
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted into intron 7 and a second loxP site followed by a frt-flanked neo cassette was inserted into intron 9. Insertion was confirmed by Southern blot analysis and PCR genotyping. (J:127207)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

List all tumor models in MMHCdb carrying Ptch1tm1Hahn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptch1 Mutation:	115 strains or lines available

Original:	J:127207 Uhmann A, et al., The Hedgehog receptor Patched controls lymphoid lineage commitment. Blood. 2007 Sep 15;110(6):1814-23
All:	41 reference(s)