Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Tacc3tm1.2Tno
Name:	transforming, acidic coiled-coil containing protein 3; targeted mutation 1.2, Tetsuo Noda
MGI ID:	MGI:3763219
Synonyms:	Tacc3D
Gene:	Tacc3  Location: Chr5:33815472-33836339 bp, + strand  Genetic Position: Chr5, 17.83 cM
Alliance:	Tacc3tm1.2Tno page

Germline Transmission:	Earliest citation of germline transmission: J:126471
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The genomic region between intron 4 and 5 was removed by cre-mediated recombination following the electroporation of embryonic stem cells with a transient cre-expression construct. The absence of protein product was confirmed by western blot analysis on protein extracted from whole E9.5 embryos. (J:126471)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Tacc3tm1.2Tno

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tacc3 Mutation:	28 strains or lines available

Original:	J:126471 Yao R, et al., TACC3 is required for the proper mitosis of sclerotome mesenchymal cells during formation of the axial skeleton. Cancer Sci. 2007 Apr;98(4):555-62
All:	2 reference(s)