Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Irak4tm1Aki
Name:	interleukin-1 receptor-associated kinase 4; targeted mutation 1, Shizuo Akira
MGI ID:	MGI:3762874
Synonyms:	IRAK-4-
Gene:	Irak4  Location: Chr15:94441495-94466198 bp, + strand  Genetic Position: Chr15, 48.55 cM, cytoband F1
Alliance:	Irak4tm1Aki page

Germline Transmission:	Earliest citation of germline transmission: J:125729
Parent Cell Line:	GSI-1 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was constructed so that exon 2 was replaced with a floxed neomycin resistance cassette. Absence of protein was confirmed by western analysis of macrophage extract from homozygotes. (J:125729)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irak4 Mutation:	30 strains or lines available

Original:	J:125729 Kawagoe T, et al., Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. J Exp Med. 2007 May 14;204(5):1013-24
All:	1 reference(s)