Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lgr4tm1.2Knis
Name:	leucine-rich repeat-containing G protein-coupled receptor 4; targeted mutation 1.2, Katsuhiko Nishimori
MGI ID:	MGI:3762641
Gene:	Lgr4  Location: Chr2:109747992-109844602 bp, + strand  Genetic Position: Chr2, 56.65 cM
Alliance:	Lgr4tm1.2Knis page

Germline Transmission:	Earliest citation of germline transmission: J:127019
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Cre mediated recombination removed an Frt-flanked neo cassette and the part of exon 18 which codes for the transmembrane and signal-transducing domains. Immunostaining confirms the absence of expression in the protruding tips of the eyelids and in epithelial cells of the cornea. (J:126813, J:127019)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	19 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lgr4 Mutation:	94 strains or lines available

Original:	J:127019 Kato S, et al., Leucine-rich repeat-containing G protein-coupled receptor-4 (LGR4, Gpr48) is essential for renal development in mice. Nephron Exp Nephrol. 2006;104(2):e63-75
All:	8 reference(s)