Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Rr320tm1.1Fier
Name:	regulatory region 320; targeted mutation 1.1, Steven Fiering
MGI ID:	MGI:3762391
Synonyms:	delta5'HS2c, Hbb-artm1.1Fier
Gene:	Rr320  Location: Chr7:103501973-103526752 bp, + strand  Genetic Position: Chr7, Syntenic
Alliance:	Rr320tm1.1Fier page

Germline Transmission:	Earliest citation of germline transmission: J:126615
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Modified regulatory region, Null/knockout, RMCE-ready) Mutation:    Intragenic deletion   Mutation details: A 1194 bp fragment spanning -10,415 to -9221 relative to the start site of mouse Hbb-y was placed into a CMV-hyTK cassette with the selectable marker flanked by inverted loxP sites and inserted into the genome by homologous recombination. Recombinase-mediated cassette exchange (RMCE) was used to create an allele without the core sequence but with the flanking sequences intact by transient expression of cre. Southern blot analysis was used to confirm the modification. (J:126615)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr320 Mutation:	0 strains or lines available

Original:	J:126615 Hu X, et al., Deletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenes. Blood. 2006 Jan 15;107(2):821-6
All:	1 reference(s)