Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cacnb2tm1.1Mfre
Name:	calcium channel, voltage-dependent, beta 2 subunit; targeted mutation 1.1, Marc Freichel
MGI ID:	MGI:3762348
Synonyms:	Cavbeta2-
Gene:	Cacnb2  Location: Chr2:14607899-14992719 bp, + strand  Genetic Position: Chr2, 10.7 cM
Alliance:	Cacnb2tm1.1Mfre page

Germline Transmission:	Earliest citation of germline transmission: J:126506
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exon 16 was removed by cre-mediated recombination. This exon encodes part of the SH3 domain and the guanylate kinase domain. The absence of protein expression was confirmed by western blot analysis on E10.5 hearts. (J:126506)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacnb2 Mutation:	50 strains or lines available

Original:	J:126506 Weissgerber P, et al., Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circ Res. 2006 Sep 29;99(7):749-57
All:	3 reference(s)