Mapk1tm1Kuta
Targeted Allele Detail
|
|
| Symbol: |
Mapk1tm1Kuta |
| Name: |
mitogen-activated protein kinase 1; targeted mutation 1, Kunio Takishima |
| MGI ID: |
MGI:3759774 |
| Synonyms: |
Erk2(floxN), Erk2flox(Neo+) |
| Gene: |
Mapk1 Location: Chr16:16801246-16865317 bp, + strand Genetic Position: Chr16, 10.53 cM
|
| Alliance: |
Mapk1tm1Kuta page
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:125594
|
| Parent Cell Line: |
E14 (ES Cell)
|
| Strain of Origin: |
129P2/OlaHsd
|
|
| Allele Type: |
|
Targeted (Conditional ready, Hypomorph) |
| Mutation: |
|
Insertion
|
| |
|
Mutation details: A floxed PGK-neo cassette was inserted in reverse direction into intron 1 and an additional loxP site was inserted into intron 3. PCR genotyping was used to confirm insertion. Authors state that this is a hypomorphic allele. Western blot analysis of extracts from brain tissue confirmed a 20% to 40% reduction in protein expression that can be corrected by the removal of the neo cassette.
(J:125594)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Mapk1 Mutation: |
40 strains or lines available
|
|
| Original: |
J:125594 Satoh Y, et al., Extracellular signal-regulated kinase 2 (ERK2) knockdown mice show deficits in long-term memory; ERK2 has a specific function in learning and memory. J Neurosci. 2007 Oct 3;27(40):10765-76 |
| All: |
3 reference(s) |
|
Analysis Tools
