Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Twist1Pde
Name:	twist basic helix-loop-helix transcription factor 1; polydactyly EMS
MGI ID:	MGI:2157489
Synonyms:	Pde, TwistJ
Gene:	Twist1  Location: Chr12:34007670-34009828 bp, + strand  Genetic Position: Chr12, 14.81 cM, cytoband B-C1
Alliance:	Twist1Pde page

Germline Transmission:	Earliest citation of germline transmission: J:60747
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Chemically induced (other) (Not Applicable) Mutation:    Undefined   Mutation details: A complementation test confirmed that Pde is an allele of Twist. Sequencing the full-length cDNA and several hundred basepairs of genomic DNA upstream of the coding region failed to reveal a mutation, suggesting that the lesion may be in a regulatory element of the gene. (J:69450) Inheritance:    Dominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Twist1 Mutation:	18 strains or lines available

Original:	J:60747 Munroe RJ, et al., Mouse mutants from chemically mutagenized embryonic stem cells. Nat Genet. 2000 Mar;24(3):318-21
All:	2 reference(s)