Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fosl2tm2.1Wag
Name:	fos-like antigen 2; targeted mutation 2.1, Erwin F Wagner
MGI ID:	MGI:3757560
Synonyms:	Fosl-2-, fra-2delta
Gene:	Fosl2  Location: Chr5:32293145-32315186 bp, + strand  Genetic Position: Chr5, 17.33 cM
Alliance:	Fosl2tm2.1Wag page

Germline Transmission:	Earliest citation of germline transmission: J:125028
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Intragenic deletion   Mutation details: ES cell containing Fosl2tm2Wag were transfected with a cre-expressing plasmid to remove the exons 3 and 4 along with a neo cassette. RNase protection and western blot were used to confirm the absence of full-length protein from mouse embryonic fibroblasts using an anti-Fosl2 antibody. However, a fusion protein with the remaining GFP open reading frame is detected using an anti-GFP antibody. (J:125028)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fosl2 Mutation:	13 strains or lines available

Original:	J:125028 Eferl R, et al., Simultaneous generation of fra-2 conditional and fra-2 knock-out mice. Genesis. 2007 Jul;45(7):447-51
All:	8 reference(s)