Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sox10tm4Weg
Name:	SRY (sex determining region Y)-box 10; targeted mutation 4, Michael Wegner
MGI ID:	MGI:3723308
Synonyms:	Sox10aa1
Gene:	Sox10  Location: Chr15:79039113-79048690 bp, - strand  Genetic Position: Chr15, 37.7 cM
Alliance:	Sox10tm4Weg page

Germline Transmission:	Earliest citation of germline transmission: J:124679
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Not Specified) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A targeting vector was constructed that contains a Sox10 open reading that changes amino acids 71-73 from CIR to AAA, followed by a loxP flanked neo cassette. The region mutated is necessary for DNA-dependent dimerization of this transcription factor. The vector replaced the entire open reading frame of Sox10 by deleting exons 3 through 5. The neo cassette was removed via in vivo Cre mediated recombination. Quantitative RT-PCR and immunoprecipitation on mid-stage embryos indicated that mRNA and protein levels of the mutated gene were similar to the wild-type gene. (J:124679)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox10 Mutation:	33 strains or lines available

Original:	J:124679 Schreiner S, et al., Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages. Development. 2007 Sep;134(18):3271-81
All:	2 reference(s)