Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bdnftm2(BDNF)Gogo
Name:	brain derived neurotrophic factor; targeted mutation 2, Joseph A Gogos
MGI ID:	MGI:3720710
Synonyms:	Bdnfval
Gene:	Bdnf  Location: Chr2:109505045-109557352 bp, + strand  Genetic Position: Chr2, 56.63 cM
Alliance:	Bdnftm2(BDNF)Gogo page

Germline Transmission:	Earliest citation of germline transmission: J:124050
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout) Mutation:    Insertion   Bdnftm2(BDNF)Gogo expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human BDNF (627) Bdnf  (MGI:88145)   Mutation details: A targeting vector was designed to replace the coding sequence with the corresponding 274 bp long human sequence carrying a valine substitution. The vector contained the self-excising ACN cassette. (J:124050)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bdnf Mutation:	39 strains or lines available

Original:	J:124050 Cao L, et al., Genetic modulation of BDNF signaling affects the outcome of axonal competition in vivo. Curr Biol. 2007 Jun 5;17(11):911-21
All:	2 reference(s)