Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Apptm1Umu
Name:	amyloid beta precursor protein; targeted mutation 1, Ulrike C Muller
MGI ID:	MGI:3718442
Synonyms:	APPsalpha-, APPsalpha-KI, APPssalpha
Gene:	App  Location: Chr16:84751236-84972187 bp, - strand  Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
Alliance:	Apptm1Umu page

Germline Transmission:	Earliest citation of germline transmission: J:123316
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Mutation details: A stop codon was introduced into exon 16 behind the alpha-secretase site at position QK612, flanked by a SV40 polyA site to ensure efficient polyadenylation of the mRNA. A floxed neo was removed via transient cre expression. (J:123316)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

24 assay results 2 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any App Mutation:	89 strains or lines available

Original:	J:123316 Ring S, et al., The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. J Neurosci. 2007 Jul 18;27(29):7817-26
All:	8 reference(s)