Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Shc1tm5Paw
Name:	src homology 2 domain-containing transforming protein C1; targeted mutation 5, Tony Pawson
MGI ID:	MGI:3716779
Synonyms:	ShcA2F
Gene:	Shc1  Location: Chr3:89325858-89337336 bp, + strand  Genetic Position: Chr3, 39.11 cM
Alliance:	Shc1tm5Paw page

Germline Transmission:	Earliest citation of germline transmission: J:122927
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Mutation details: A targeting vector was used to insert cDNA containing YY239-240FF substitutions with a single Flag-pA epitope tag and a floxed neo into exon 3, replacing the exon 4 of the locus. (J:122927)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Shc1tm5Paw

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Shc1 Mutation:	66 strains or lines available

Original:	J:122927 Hardy WR, et al., Combinatorial ShcA docking interactions support diversity in tissue morphogenesis. Science. 2007 Jul 13;317(5835):251-6
All:	4 reference(s)