Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Ttr-KLF6)1Fdmn
Name:	transgene insertion 1, Scott Friedman
MGI ID:	MGI:3716726
Synonyms:	TTR1-KLF6
Transgene:	Tg(Ttr-KLF6)1Fdmn  Location: unknown
Alliance:	Tg(Ttr-KLF6)1Fdmn page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Ttr-KLF6)1Fdmn expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human KLF6 (1316) Klf6  (MGI:1346318)   Mutation details: The tranthyretin promoter was fused to the human KLF6 cDNA to induce hepatoyte-specific overexpresson that is two- to three-fold above normal levels. Expression is localized to hepatocytes with variable expression in the choroid plexus of the brain at high transgene copy number. In addition to transgenic line 1, lines 4 and 9 were also made. (J:122903)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:122903 Narla G, et al., In vivo regulation of p21 by the Kruppel-like factor 6 tumor-suppressor gene in mouse liver and human hepatocellular carcinoma. Oncogene. 2007 Jun 28;26(30):4428-34
All:	1 reference(s)