Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Leprdb-lb
Name:	leptin receptor; pound
MGI ID:	MGI:3714780
Synonyms:	Leprdb-lb, pound
Gene:	Lepr  Location: Chr4:101574601-101672549 bp, + strand  Genetic Position: Chr4, 46.96 cM
Alliance:	Leprdb-lb page

Strain of Origin:

C57BL/6NCrl

Allele Type:    Spontaneous Mutations:    Intragenic deletion, Inversion   Mutation details: This mutation resulted from a spontaneous deletion/inversion event that removed exon 2, containing the initiation codon, from the leptin receptor gene. Splicing of the mutant transcript joins exon 1 to exon 3. While there is an initiation codon in exon 3, it is not in frame and its use leads to immediate termination of translation. (J:171755) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:	121 strains or lines available

Original:	J:171755 Baldwin W, et al., Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome. Diabetes. 2011 Apr;60(4):1258-69
All:	1 reference(s)