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Runx1tm1(cre/Esr1*)Ims
Targeted Allele Detail
Nomenclature
Symbol: Runx1tm1(cre/Esr1*)Ims
Name: runt related transcription factor 1; targeted mutation 1, Igor M Samokhvalov
MGI ID: MGI:3711451
Synonyms: Runx1Cre, Runx1CreER, Runx1MER-Cre-MER, Runx1tm1(cre)Ims
Gene: Runx1  Location: Chr16:92601466-92826074 bp, - strand  Genetic Position: Chr16, 53.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121435
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Hypomorph, Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a tamoxifen-inducible cre recombinase flanked by two mutated estrogen receptors and a floxed neo into the Runx1 gene downstream of the proximal (P2) promoter. The neo was subsequently removed via exogenous cre expression. A subsequent reference states that the allele was determined to be hypomorphic, with homozygotes developing to term but dying in the first postnatal day. (J:121435, J:182232)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Runx1     Summary of all recombinase alleles driven by Runx1. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 14 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:  12 strains or lines available
References
Original:  J:121435 Samokhvalov IM, et al., Cell tracing shows the contribution of the yolk sac to adult haematopoiesis. Nature. 2007 Apr 26;446(7139):1056-61
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory