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Tg(Wap-Tsg101)4389Kuw
Transgene Detail
Nomenclature
Symbol: Tg(Wap-Tsg101)4389Kuw
Name: transgene insertion 4389, Kay-Uwe Wagner
MGI ID: MGI:3710126
Transgene: Tg(Wap-Tsg101)4389Kuw  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsAn HA-tagged Tsg101 cDNA was cloned into the blunted Asp718 and SalI sites of a WAP-based mammary specific expression vector replacing exons 1-3 of WAP. Expression of Tsg101 is thus under the control of the WAP promoter. (J:121475)
Phenotypes
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:121475 Oh KB, et al., Tsg101 is upregulated in a subset of invasive human breast cancers and its targeted overexpression in transgenic mice reveals weak oncogenic properties for mammary cancer initiation. Oncogene. 2007 Aug 30;26(40):5950-9
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory