Fkbp5Gt(RRC236)Byg
Gene trapped Allele Detail
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| Symbol: |
Fkbp5Gt(RRC236)Byg |
| Name: |
FK506 binding protein 5; gene trap RRC236, BayGenomics |
| MGI ID: |
MGI:3710108 |
| Synonyms: |
Fkbp51- |
| Gene: |
Fkbp5 Location: Chr17:28617727-28705123 bp, - strand Genetic Position: Chr17, 14.66 cM
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| Alliance: |
Fkbp5Gt(RRC236)Byg page
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| Mutant Cell Line: |
RRC236 |
| Germline Transmission: |
Earliest citation of germline transmission:
J:120960
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| Parent Cell Line: |
Other (see notes) (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Gene trapped (Null/knockout, Reporter) |
| Mutation: |
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Insertion of gene trap vector
Vector: pGT1Lxf
Vector Type: gene trap
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Mutation details: The pGT1Lxf gene trap vector that contains a splice acceptor and beta-geo was inserted into intron 4. Northern blot, quantitative RT-PCR and Western blot confirmed the expression of a fusion transcript and protein that lacked the peptidyl-prolyl cis/trans-isomerase-like domain and all three TPR domains critical for the protein's function.
(J:120960)
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| Sequence Tags: |
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Sequence tag details (1 tag)
| Tag ID |
GenBank ID |
Method |
Tag Location (trapped strand)* |
Select |
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| Genome Context: |
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Genome Browser view of this mutation
178 gene trap insertions have trapped this gene
View all gene trap sequence tags in this region
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Fkbp5 Mutation: |
169 strains or lines available
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All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
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| Original: |
J:120960 Yong W, et al., Essential role for Co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology. J Biol Chem. 2007 Feb 16;282(7):5026-36 |
| All: |
7 reference(s) |
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Analysis Tools
