Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol: Sphk1tm2Cgh Name: sphingosine kinase 1; targeted mutation 2, Shaun R Coughlin MGI ID: MGI:3707997 Synonyms: Sphk1f Gene: Sphk1  Location: Chr11:116421751-116427501 bp, + strand  Genetic Position: Chr11, 81.42 cM, cytoband E2 Alliance: Sphk1tm2Cgh page

Impaired lymphocyte egress in Lyve1tm1.1(EGFP/cre)Cys/Lyve1+ Sphk1tm2Cgh/Sphk1tm2Cgh Sphk2tm1.1Cgh/Sphk2tm1.1Cgh mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:120783
Parent Cell Line:	RF8 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An FRT-flanked neo cassette with a single 3' loxP site was inserted between exons 2 and 3 and an additional loxP site was inserted downstream of exon 6. The neo cassette was subsequently removed through flp mediated recombination. (J:120783)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sphk1 Mutation:	30 strains or lines available

Original:	J:120783 Pappu R, et al., Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science. 2007 Apr 13;316(5822):295-8
All:	23 reference(s)