Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Chd7Gt(S20-7E1)Sor Name: chromodomain helicase DNA binding protein 7; gene trap S20-7E1, Philippe Soriano MGI ID: MGI:3707678 Synonyms: Chd7Gt, Chd7Gt1Dmm, Chd7Gt(FHCRC-GT-S20-7E1)Sor, Chd7Gt(ROSAFARY)1Dmm Gene: Chd7  Location: Chr4:8690406-8867659 bp, + strand  Genetic Position: Chr4, 3.68 cM Alliance: Chd7Gt(S20-7E1)Sor page

Abnormal development in Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor mice and delayed turning in Chd7Gt(S20-7E1)Sor/Chd7+ embryos Show the 2 phenotype image(s) involving this allele.

Mutant Cell Line:	S20-7E1
Germline Transmission:	Earliest citation of germline transmission: J:119812
Parent Cell Line:	AK7.1 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector     Vector: ROSAFARY   Mutation details: The gene trap vector ROSAFARY was inserted between exon 1 and 2 creating an exon 1/lacZ fusion transcript and an hyg fusion transcript with the remainder of the coding region. The absence of the normal splice product and the production of the two mutant variants was confirmed by RT-PCR. (J:119812) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select FHCRC-GT-S20-7E1 CL706141 (MGI Seq Detail) 3' RACE Chr4:8751326-8785603 bp (+) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 25 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	220 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	39 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chd7 Mutation:	136 strains or lines available

Original:	J:119812 Hurd EA, et al., Loss of Chd7 function in gene-trapped reporter mice is embryonic lethal and associated with severe defects in multiple developing tissues. Mamm Genome. 2007 Feb;18(2):94-104
All:	19 reference(s)