Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Abca3tm1Frm
Name:	ATP-binding cassette, sub-family A member 3; targeted mutation 1, Mason W Freeman
MGI ID:	MGI:3706347
Gene:	Abca3  Location: Chr17:24570997-24629178 bp, + strand  Genetic Position: Chr17, 12.38 cM, cytoband A3.3
Alliance:	Abca3tm1Frm page

Germline Transmission:	Earliest citation of germline transmission: J:120296
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/SvEv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 4 and 5 are replaced with a zeo/neo cassette. The null allele was confirmed by the absence of protein in a western blot of homozygous embryonic tissue. (J:120296)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abca3 Mutation:	92 strains or lines available

Original:	J:120296 Fitzgerald ML, et al., ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol. J Lipid Res. 2007 Mar;48(3):621-32
All:	1 reference(s)