FlnbGt(BGB085)Byg
Gene trapped Allele Detail
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| Symbol: |
FlnbGt(BGB085)Byg |
| Name: |
filamin, beta; gene trap BGB085, BayGenomics |
| MGI ID: |
MGI:3704947 |
| Gene: |
Flnb Location: Chr14:14518185-14651816 bp, - strand Genetic Position: Chr14, 4.59 cM
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| Alliance: |
FlnbGt(BGB085)Byg page
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Skeletal abnormalities in FlnbGt(BGB085)Byg/FlnbGt(BGB085)Byg mice
Show the 2 phenotype image(s) involving this allele.
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| Mutant Cell Line: |
BGB085 |
| Germline Transmission: |
Earliest citation of germline transmission:
J:120066
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| Parent Cell Line: |
Other (see notes) (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Gene trapped (Null/knockout, Reporter) |
| Mutation: |
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Insertion of gene trap vector
Vector: pGT1Lxf
Vector Type: gene trap
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Mutation details: A BayGenomics gene trap vector (pGT1lxf) was inserted into intron 20 to create an in frame 5' fusion product with a lacZ cassette. The absence of the 250KDa protein was confirmed by western blot with an antibody recognizing the C-terminus end of Flnb. A beta-galactosidase assay confirmed expression of the lacZ fusion product.
(J:120066)
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| Sequence Tags: |
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Sequence tag details (1 tag)
| Tag ID |
GenBank ID |
Method |
Tag Location (trapped strand)* |
Select |
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| Genome Context: |
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Genome Browser view of this mutation
94 gene trap insertions have trapped this gene
View all gene trap sequence tags in this region
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Flnb Mutation: |
151 strains or lines available
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All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
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| Original: |
J:120066 Zhou X, et al., Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3919-24 |
| All: |
2 reference(s) |
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Analysis Tools
