Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Pdx1tm4Cvw
Name:	pancreatic and duodenal homeobox 1; targeted mutation 4, Christopher VE Wright
MGI ID:	MGI:3702084
Synonyms:	Ipf1tm3Cvw, Pdx1flE2, Pdx1tm4(E2)Cvw
Gene:	Pdx1  Location: Chr5:147206907-147212658 bp, + strand  Genetic Position: Chr5, 86.84 cM
Alliance:	Pdx1tm4Cvw page

Germline Transmission:	Earliest citation of germline transmission: J:130389
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion     LoxP sites for Cre recombinase were inserted to flank exon 2 of the gene. (J:130389)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pdx1 Mutation:	35 strains or lines available

Original:	J:130389 Gannon M, et al., pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol. 2008 Feb 15;314(2):406-17
All:	12 reference(s)