Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sox10tm3(Sox8)Weg
Name:	SRY (sex determining region Y)-box 10; targeted mutation 3, Michael Wegner
MGI ID:	MGI:3701358
Synonyms:	Sox10Sox8ki
Gene:	Sox10  Location: Chr15:79039113-79048690 bp, - strand  Genetic Position: Chr15, 37.7 cM
Alliance:	Sox10tm3(Sox8)Weg page

Germline Transmission:	Earliest citation of germline transmission: J:119015
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted Mutations:    Insertion, Intragenic deletion   Mutation details: The Sox8 open reading frame along with an IRES-EGFP and a floxed neo cassette were inserted into exon 3, replacing the entire open reading frame of Sox10. The neo cassette was removed via in vivo Cre mediated recombination. (J:119015)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox10 Mutation:	33 strains or lines available

Original:	J:119015 Kellerer S, et al., Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence. Development. 2006 Aug;133(15):2875-86
All:	2 reference(s)