Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	H2-M3tm1Crw
Name:	histocompatibility 2, M region locus 3; targeted mutation 1, Chung-Ru Wang
MGI ID:	MGI:3701255
Synonyms:	M3-
Gene:	H2-M3  Location: Chr17:37581111-37585375 bp, + strand  Genetic Position: Chr17, 19.16 cM
Alliance:	H2-M3tm1Crw page

Germline Transmission:	Earliest citation of germline transmission: J:118960
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     A neomycin resistance gene replaced exons 4-6 by homologous recombination. (J:118960)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any H2-M3 Mutation:	15 strains or lines available

Original:	J:118960 Xu H, et al., Impaired response to Listeria in H2-M3-deficient mice reveals a nonredundant role of MHC class Ib-specific T cells in host defense. J Exp Med. 2006 Feb 20;203(2):449-59
All:	10 reference(s)