Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Runx1tm1(RUNX1/EVI1)Kmit
Name:	runt related transcription factor 1; targeted mutation 1, Kinuko Mitani
MGI ID:	MGI:3701004
Synonyms:	AML1/EVI1
Gene:	Runx1  Location: Chr16:92398354-92622962 bp, - strand  Genetic Position: Chr16, 53.7 cM
Alliance:	Runx1tm1(RUNX1/EVI1)Kmit page

Germline Transmission:	Earliest citation of germline transmission: J:118892
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Mutation details: A targeting vector was designed to replace exon 5 with a chimeric cDNA encoding the human runt related transcription factor 1 exon 5 and the human ecotopic viral integration site 1 into exon 5. Successful expression of the chimeric mice/human transcript was confirmed by Northern blot. (J:118892)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:	35 strains or lines available

Original:	J:118892 Maki K, et al., Dysplastic definitive hematopoiesis in AML1/EVI1 knock-in embryos. Blood. 2005 Sep 15;106(6):2147-55
All:	1 reference(s)