Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ptger1tm1Crjk
Name:	prostaglandin E receptor 1 (subtype EP1); targeted mutation 1, Chris R J Kennedy
MGI ID:	MGI:3700011
Synonyms:	EP1-
Gene:	Ptger1  Location: Chr8:84393307-84399382 bp, + strand  Genetic Position: Chr8, 40.22 cM
Alliance:	Ptger1tm1Crjk page

Germline Transmission:	Earliest citation of germline transmission: J:118519
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Nucleotide substitutions   Mutation details: A mutation was introduced resulting in a stop codon in the coding region at amino acid position 242, thereby halting translation at the beginning of the third cytoplasmic loop. (J:118519)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptger1 Mutation:	22 strains or lines available

Original:	J:118519 Kennedy CR, et al., Urine concentrating defect in prostaglandin EP1-deficient mice. Am J Physiol Renal Physiol. 2007 Feb;292(2):F868-75
All:	5 reference(s)