Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pax68Neu
Name:	paired box 6; 8, Neuherberg
MGI ID:	MGI:2156819
Synonyms:	TX-12
Gene:	Pax6  Location: Chr2:105499245-105527709 bp, + strand  Genetic Position: Chr2, 55.31 cM
Alliance:	Pax68Neu page

Strain of Origin:

(102 x C3H)F1

Allele Type:    Chemically and radiation induced Mutation:    Single point mutation   Mutation details: The mutation, which was induced by treatment of a male mouse with a combination of triethylenemelamine (TEM) and 6Gy radiation, was identified as a C to A substitution in exon 10, nucleotide position 1092. The resulting protein has a Tyr to Stop substitution at amino acid position 310. The mutation resides in the P/S/T region of the protein. (J:73625)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pax6 Mutation:	90 strains or lines available

Original:	J:63651 Favor J, et al., Saturation mutagenesis for dominant eye morphological defects in the mouse Mus musculus. Mamm Genome. 2000 Jul;11(7):520-5
All:	2 reference(s)