Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol: Kcne2tm1Gwab Name: potassium voltage-gated channel, Isk-related subfamily, gene 2; targeted mutation 1, Geoffrey W Abbott MGI ID: MGI:3699589 Synonyms: Kcne2- Gene: Kcne2  Location: Chr16:92089277-92095017 bp, + strand  Genetic Position: Chr16, 53.55 cM Alliance: Kcne2tm1Gwab page

Kcne2tm1Gwab/Kcne2tm1Gwab mice have enlarged stomachs Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:116518
Parent Cell Line:	RF8 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was replaced with a neomycin resistance cassette. Western blot confirmed absence of protein in mutant stomach samples. (J:116518)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

List all tumor models in MMHCdb carrying Kcne2tm1Gwab

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcne2 Mutation:	10 strains or lines available

Original:	J:116518 Roepke TK, et al., The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion. J Biol Chem. 2006 Aug 18;281(33):23740-7
All:	14 reference(s)