Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ren1tm1Bjm
Name:	renin 1 structural; targeted mutation 1, Brian J Morris
MGI ID:	MGI:3699140
Synonyms:	REKO
Gene:	Ren1  Location: Chr1:133278412-133288058 bp, + strand  Genetic Position: Chr1, 57.91 cM
Alliance:	Ren1tm1Bjm page

Germline Transmission:	Earliest citation of germline transmission: J:117294
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Modified regulatory region, Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting construct was designed to replace the enhancer with a floxed pgk-neo cassette that was subsequently removed via cre-mediated recombination. (J:117294)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ren1 Mutation:	36 strains or lines available

Original:	J:117294 Adams DJ, et al., Renin enhancer is critical for control of renin gene expression and cardiovascular function. J Biol Chem. 2006 Oct 20;281(42):31753-61
All:	2 reference(s)