Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Sh3bp2tm1Bjro
Name:	SH3-domain binding protein 2; targeted mutation 1, Bjorn R Olsen
MGI ID:	MGI:3698401
Synonyms:	Sh3bp2KI
Gene:	Sh3bp2  Location: Chr5:34683182-34720985 bp, + strand  Genetic Position: Chr5, 17.89 cM
Alliance:	Sh3bp2tm1Bjro page

Germline Transmission:	Earliest citation of germline transmission: J:117880
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Humanized sequence) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A proline to arginine mutation was inserted into exon 9 (P416R). A floxed neo included in the vector was subsequently removed from the locus. (J:117880)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

18 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sh3bp2 Mutation:	35 strains or lines available

Original:	J:117880 Ueki Y, et al., Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 'cherubism' mice. Cell. 2007 Jan 12;128(1):71-83
All:	14 reference(s)