Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Notch2tm1Frad
Name:	notch 2; targeted mutation 1, Freddy Radtke
MGI ID:	MGI:3695412
Synonyms:	N2-, Notch2flox
Gene:	Notch2  Location: Chr3:97920854-98057683 bp, + strand  Genetic Position: Chr3, 42.42 cM
Alliance:	Notch2tm1Frad page

Germline Transmission:	Earliest citation of germline transmission: J:125373
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	BALB/c

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A floxed neomycin resistance cassette was inserted in the intron between exons c2 and d. A third loxP was inserted in the intron between exons e and f. The floxed neo was subsequently removed from one correctly targeted ES cell clone using a cre expression vector. Resulting mice have loxP sites flanking exons d and e. (J:125373)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Notch2 Mutation:	97 strains or lines available

Original:	J:125373 Besseyrias V, et al., Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation. J Exp Med. 2007 Feb 19;204(2):331-43
All:	25 reference(s)