Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rettm13.1Jmi
Name:	ret proto-oncogene; targeted mutation 13.1, Jeffrey Milbrandt
MGI ID:	MGI:3691588
Synonyms:	RET-, Ret-EGFP, RETEGFP
Gene:	Ret  Location: Chr6:118128706-118174679 bp, - strand  Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
Alliance:	Rettm13.1Jmi page

Germline Transmission:	Earliest citation of germline transmission: J:114682
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site and the human RET (RET9) sequence was inserted with a floxEGFPfrt-neo-frt cassette. The neo was removed by flp mediated recombination. This allele allows EGFP expression upon the cre mediated deletion of floxed cDNA from exon 1. Cre-mediated recombination removed the cDNA and allows for the expression of the reporter gene. (J:114682)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	26 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ret Mutation:	53 strains or lines available

Original:	J:114682 Jain S, et al., RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice. J Neurosci. 2006 Oct 25;26(43):11230-8
All:	13 reference(s)