Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Pik3catm1Jjz
Name:	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 1, Jean J Zhao
MGI ID:	MGI:3691486
Synonyms:	p110alphaflox, p110alpha flox
Gene:	Pik3ca  Location: Chr3:32451203-32520256 bp, + strand  Genetic Position: Chr3, 15.7 cM, cytoband B
Alliance:	Pik3catm1Jjz page

Germline Transmission:	Earliest citation of germline transmission: J:115274
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Exon 1 was flanked by lox P sites, with an FRT-flanked selection cassette between exon 1 and the downstream loxP site. The selection cassette was subsequently removed from the locus via transient transfection with a FLP recombinase plasmid. (J:115274)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

List all tumor models in MMHCdb carrying Pik3catm1Jjz

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pik3ca Mutation:	62 strains or lines available

Original:	J:115274 Zhao JJ, et al., The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16296-300
All:	33 reference(s)