Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Erbb3tm1Squ
Name:	erb-b2 receptor tyrosine kinase 3; targeted mutation 1, Shimian Qu
MGI ID:	MGI:3690339
Synonyms:	ErbB3fl, ErbB3GIAS
Gene:	Erbb3  Location: Chr10:128403392-128425504 bp, - strand  Genetic Position: Chr10, 77.1 cM
Alliance:	Erbb3tm1Squ page

Germline Transmission:	Earliest citation of germline transmission: J:114524
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A IRES-GFP was inserted into intron 1 in reverse orientation and flanked by loxP sites in the opposite orientation. The cassette contained a splice acceptor sequence and a polyA signal. (J:114524)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erbb3 Mutation:	47 strains or lines available

Original:	J:114524 Qu S, et al., Gene targeting of ErbB3 using a Cre-mediated unidirectional DNA inversion strategy. Genesis. 2006 Oct;44(10):477-86
All:	9 reference(s)