Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Myh6tm2Ces
Name:	myosin, heavy polypeptide 6, cardiac muscle, alpha; targeted mutation 2, Christine E Seidman
MGI ID:	MGI:3690300
Synonyms:	MHCS532P
Gene:	Myh6  Location: Chr14:55179378-55204384 bp, - strand  Genetic Position: Chr14, 28.01 cM
Alliance:	Myh6tm2Ces page

Germline Transmission:	Earliest citation of germline transmission: J:114549
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted Mutation:    Nucleotide substitutions     The S532P mutation was inserted into exon 16. (J:114549)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myh6 Mutation:	206 strains or lines available

Original:	J:114549 Schmitt JP, et al., Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14525-30
All:	3 reference(s)