Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Acvr2btm1Spo
Name:	activin receptor IIB; targeted mutation 1, S Paul Oh
MGI ID:	MGI:3690298
Synonyms:	Acvr2b4(neo)
Gene:	Acvr2b  Location: Chr9:119231184-119264061 bp, + strand  Genetic Position: Chr9, 71.33 cM
Alliance:	Acvr2btm1Spo page

Germline Transmission:	Earliest citation of germline transmission: J:114533
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert a modified exon 4 such that it was fused to exon 3 as well as a floxed neo cassette that was inserted into exon 4. This mutation resulted in the expression of the shortest isoform only, as shown by Northern blot analysis. (J:114533)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acvr2b Mutation:	27 strains or lines available

Original:	J:114533 Lee YJ, et al., Generation of activin receptor type IIB isoform-specific hypomorphic alleles. Genesis. 2006 Oct;44(10):487-94
All:	1 reference(s)