Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dtx2tm1Mjb
Name:	deltex 2, E3 ubiquitin ligase; targeted mutation 1, Michael J Bevan
MGI ID:	MGI:3690125
Synonyms:	Dx2-KO
Gene:	Dtx2  Location: Chr5:136023654-136061726 bp, + strand  Genetic Position: Chr5, 75.64 cM
Alliance:	Dtx2tm1Mjb page

Germline Transmission:	Earliest citation of germline transmission: J:114658
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exons 1 and 2 were deleted via FLP mediated recombination. This sequence contained the ATG and encodes the first 301 amino acids of the protein and both WWE repeats. The presence of a truncated transcript was confirmed by Northern blot analysis of splenocytes. (J:114658)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dtx2 Mutation:	55 strains or lines available

Original:	J:114658 Lehar SM, et al., T cells develop normally in the absence of both Deltex1 and Deltex2. Mol Cell Biol. 2006 Oct;26(20):7358-71
All:	2 reference(s)