Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	TnfR8H
Name:	tumor necrosis factor; R8H
MGI ID:	MGI:3689190
Gene:	Tnf  Location: Chr17:35418357-35420983 bp, - strand  Genetic Position: Chr17, 18.59 cM
Alliance:	TnfR8H page

Strain of Origin:

I/St

Allele Type:    Spontaneous Mutation:    Nucleotide substitutions   Mutation details: A nonsynonymous G>A substitution was found at coding cDNA nucleotide 23 (c.23G>A) in exon 1 in the I/St strain. The amino-acid substitution was positioned in the cytoplasmic region of the leader sequence in the propeptide, changing amino-acid 8 from arginine to histidine (p.R8H or p.Arg8His). (J:114302)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnf Mutation:	46 strains or lines available

Original:	J:114302 Kahler AK, et al., A new coding mutation in the Tnf-alpha leader sequence in tuberculosis-sensitive I/St mice causes higher secretion levels of soluble TNF-alpha. Genes Immun. 2005 Oct;6(7):620-7
All:	1 reference(s)