Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Akr1b1tm1Tona
Name:	aldo-keto reductase family 1 member B; targeted mutation 1, Toshimasa Onaya
MGI ID:	MGI:3689185
Synonyms:	Akr1b1-
Gene:	Akr1b1  Location: Chr6:34280865-34294424 bp, - strand  Genetic Position: Chr6, 14.87 cM, cytoband B1
Alliance:	Akr1b1tm1Tona page

Germline Transmission:	Earliest citation of germline transmission: J:114187
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into exon 1. Wester blot failed to detect protein in mutants. (J:114187)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akr1b1 Mutation:	27 strains or lines available

Original:	J:114187 Aida K, et al., Disruption of aldose reductase gene (Akr1b1) causes defect in urinary concentrating ability and divalent cation homeostasis. Biochem Biophys Res Commun. 2000 Oct 22;277(2):281-6
All:	1 reference(s)